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NCT Number: NCT05628324

EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

The purpose of this study is to develop and test if upper limb task practice and muscle activity training improve upper limb function in stroke survivors. Participants will be asked to come to the laboratory 23 times (approximately 3 times a week) over 2.5 months to receive upper limb task practice, muscle activity training, and/or upper extremity functional assessments.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ralph H. Johnson VA Medical Center, Charleston, SC

Charleston, South Carolina, 29401-5703, United States

Location status: Recruiting

Location contact

Na Jin Seo, PhD MS BS

PRINCIPAL_INVESTIGATOR

Sarah A Jackson, BA MA

CONTACT

[email protected]

843-789-6700

About this study

The purpose of this study is to develop and test if upper limb task practice and muscle activity training improve upper limb function in stroke survivors. Participants will be asked to come to the laboratory 23 times (approximately 3 times a week) over 2.5 months to receive upper limb task practice, muscle activity training, and/or upper extremity functional assessments.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18+ years old
  • Stroke more than 6 months ago
  • Moderate unilateral upper limb impairment
  • Cognitive ability to participate in the study procedure
  • Ability to see the full computer screen

Exclusion criteria

  • Concurrent upper limb rehabilitation
  • Inability to voluntarily contract muscles of at least 2 upper limb muscle groups, prohibiting participation in training
  • Change in spasticity medication or botulinum toxin injection in the upper limb within 3 months prior to or during enrollment
  • Total sensory loss
  • Comorbidity (e.g., orthopaedic or premorbid neurologic condition) that limit upper limb movement and/or participation in the intervention
  • Language barrier or cognitive impairment that precludes providing consent

Treatment and study plan

practice muscle activation patterns

Behavioral

practice upper limb muscle activation patterns using EMG-controlled games

task practice

Behavioral

practice functional upper limb tasks

Primary outcomes

  1. Wolf Motor Function Test

    Time frame: Within 1 week from intervention completion

    Functional abilities scale for completing upper limb tasks

Study contacts

Contact information is provided by the study sponsor or research team.

Sarah A Jackson, BA MA

CONTACT

[email protected]

(843) 789-6700

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Registry information

Acronym: GAM

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Nov 28, 2022
Registry last updated
Aug 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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