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Enrolling by Invitation

NCT Number: NCT07527871

Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.

Enrolling by Invitation

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Key information

Conditions

Substance Use (Drugs, Alcohol) Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Ohio State University Wexner Medical Center

Columbus, Ohio, 43201, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult at least 18 years of age
  • Capacity and willingness to participate (including reliable phone or internet access for counseling session)
  • Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.

Exclusion criteria

  • A priori participant request for participation
  • Previously enrolled in this or other study of substance use disorder prevention
  • Language other than English
  • Expected/actual ED disposition of hospitalization or non-independent status
  • Prisoner at time of enrollment
  • Known to be pregnant at time of enrollment
  • Past substance use disorder or substance use treatment
  • High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone

Treatment and study plan

ED-SMART intervention

Behavioral

The ED-SMART intervention will include: (i) a brief (approximately 15 minutes) counseling session in the emergency department and (ii) five, monthly brief counseling sessions (approximately 15 to 30 minutes) delivered by telehealth. These sessions will focus on creating individualized strategies to help participants reach their alcohol and substance use reduction goals

Substance use information

Behavioral

The substance use information condition will receive printed health information covering information about substance use (e.g., definitions, hazards, potential for addiction, injury, and other consequences). Research staff will also discuss ways to utilize primary care or establish care with a primary care provider to provide ongoing follow-up.

Primary outcomes

  1. Self-reported substance use

    Time frame: From baseline to the sixth month follow-up assessment

    Self-reported substance use frequency

Secondary outcomes

  1. Self-reported substance use quantity

    Time frame: From baseline to the six month follow-up

    Self-reported substance use quantity for each substance

  2. Incidence of positive substance use disorder screen

    Time frame: From baseline to the six month follow-up

    Incidence of positive substance use disorder screen as measured by the NIDA Modified ASSIST or AUDIT

  3. Toxicology assays for substance use

    Time frame: From baseline to the six month follow-up assessment

    Proportion with positive toxicology assay for substance use

  4. Self-reported healthcare utilization

    Time frame: Baseline to the six month follow-up assessment

    Self-reported healthcare utilization

  5. Fatal and non-fatal overdose

    Time frame: Baseline to the six month follow-up assessment

    Frequency of fatal and non-fatal overdose

Sponsors and collaborators

Lead sponsor

Purdue University

Other

Collaborators

  • Centers for Disease Control and Prevention

Registry information

Official study title

ED-SMART: Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

Acronym: ED-SMART

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Apr 14, 2026
Registry last updated
Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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