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Completed

NCT Number: NCT04288284

Emergency Curative Resection of Colorectal Cancer

The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Disease Attributes Emergencies Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Oncologic Complications and Emergencies Pathologic Processes Pathological Conditions, Signs and Symptoms Rectal Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

About this study

60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients presented with Potentially operable colorectal cancer
  • No clinical or radiological evidence of metastatic disease

Exclusion criteria

  • Patients received preoperative chemoradiation
  • Patients with clinical or radiological evidence of metastatic disease
  • Patients with intraoperative evidence of metastatic disease
  • Patients with intraoperative evidence of irresectable disease
  • Patients with incomplete follow up

Treatment and study plan

Curative resection of colorectal cancer

Procedure

Primary outcomes

  1. Adequate oncologic resection

    Time frame: histopathological assessment of surgical specimens within 2 weeks postoperative

    Negative resection margins + adequate lymphadenectomy ( Lymph Nodes retrieved > 12)

  2. early postoperative mortality after curative resection of colorectal cancer

    Time frame: within 90 days after surgery

    early death due to cause related to surgery

  3. early postoperative morbidity after curative resection of colorectal cancer

    Time frame: within 90 days after surgery

    surgery-related complications

Secondary outcomes

  1. Tumor recurrence

    Time frame: By the end of the 3 years follow up period

    either local or distant

  2. Disease free survival

    Time frame: By the end of the 3 years follow up period

    % of patients survived without recurrence

  3. Overall survival

    Time frame: By the end of the 3 years follow up period

    % of all patients survived either with or without recurrence

Sponsors and collaborators

Lead sponsor

University of Alexandria

Other

Registry information

Official study title

Emergency Curative Resection of Colorectal Cancer, Do it With Caution. A Comparative Case Series

Important dates

Study start
2015
Primary completion
2019
Study completion
2020
First posted
Feb 28, 2020
Registry last updated
Feb 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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