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OpenTrials
Completed

NCT Number: NCT03350230

Embryonic Ploidy Status in the Oncofertility Population

looking at aneuploidy rates in embryos from patients who are going to or have undergone treatment for a malignancy with gonadotoxic treatment.

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Key information

Conditions

Oncology Fertility Neoplasms

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Reproductive Medicine Associates of New Jersey

Basking Ridge, New Jersey, 07920, United States

About this study

The study involves oncofertility patients--individuals who are undergoing or have undergone therapy for a malignancy--who are interested in pursuing or preserving fertility. In particular, it investigates chromosomal abnormalities or aneuploidy in the embryos of those individuals as compared to the general infertility population. Embryonic aneuploidy is largely due to reproductive senescence. As such the investigators will discuss oncofertility prevalence and treatment as well as reproductive senescence and assessment of embryonic aneuploidy. The study will seek to determine if there are changes in embryonic aneuploidy rates in oncofertility patients that differ from simple age related risks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1.Present or past oncologic diagnosis requiring potentially gonadotoxic treatment

Exclusion criteria

  • Oocyte banking
  • Use of oocyte donation
  • Any contraindications to undergoing in vitro fertilization or gonadotropin stimulation
  • Single gene disorder requiring more detailed embryo genetic analysis

Treatment and study plan

Primary outcomes

  1. embryonic aneuploidy rates

    Time frame: 1 month

    to evaluate the incidence of embryonic aneuploidy among oncofertility patients compared to the general infertility population

Sponsors and collaborators

Lead sponsor

Reproductive Medicine Associates of New Jersey

Other

Registry information

Important dates

Study start
2017
Primary completion
2020
Study completion
2022
First posted
Nov 22, 2017
Registry last updated
May 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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