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OpenTrials
Completed

NCT Number: NCT01490515

Embryo Selection Using Non-invasive Metabolomic Analysis Versus Morphology

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The investigators intended to investigate if embryo assessment using non-invasive metabolomic profiling leads to increased implantation rates compared to routine morphology evaluation alone.

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Key information

Conditions

Embryo Viability

Age range

18 year–49 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Eugonia ART Unit

Athens, Attica, 16561, Greece

About this study

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The aim of the present study was to determine whether embryo selection using non-invasive metabolomic profiling as an adjunct to morphology leads to increased implantation rates compared to routine morphology evaluation alone.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with at least 4 fertilized oocytes

Exclusion criteria

  • patients with less that 4 fertilized oocytes

Treatment and study plan

non-invasive metabolomic profiling

Procedure

non-invasive metabolomic profiling of IVF human embryos

Other names: ViaMetrics-E, Molecular Biometrics

morphological evaluation

Other

Simple microscopic observation of embryos and evaluation of morphological characteristics

Primary outcomes

  1. Implantation rates

    Time frame: 6 weeks of pregnancy

    To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.

Sponsors and collaborators

Lead sponsor

Eugonia

Other

Registry information

Official study title

Embryo Selection Using Non-invasive Metabolomic Analysis Indicates Improvement in Implantation Rates With Fetal Cardiac Activity

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Dec 13, 2011
Registry last updated
Dec 16, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.