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Completed

NCT Number: NCT01955356

Embryo Implantation After Induced Endometrial Injury

Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure.

The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF

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Key information

Conditions

Sterility Genital Diseases Infertility Urogenital Diseases

Age range

19 year–44 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

IVI Valencia

Valencia, 46015, Spain

About this study

Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown.

We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques.

For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 19-44 aged women
  • 19-29.9 Kg/m2.
  • 1st or 2nd fresh embryo transfer ( egg donation).
  • 1 or 2 blastocysts available.
  • written agreement.
  • > or = 6 mms endometrial thickness.

Exclusion criteria

  • Premature ovarian failure.
  • Endometrial pathology.
  • Insufficient endometrial development.
  • Hydrosalpinx
  • Mullerian malformations.

Treatment and study plan

Scratching

Procedure

Endometrial biopsy

Other names: Endometrial induced injury

Primary outcomes

  1. Ongoing implantation rate (OIR)

    Time frame: 12 weeks of pregnancy

Secondary outcomes

  1. Live born rate (LBR)

    Time frame: 9 months after embryo transfer

Sponsors and collaborators

Lead sponsor

Instituto Valenciano de Infertilidad, IVI VALENCIA

Other

Collaborators

  • IVI Barcelona
  • IVI Bilbao
  • IVI Madrid
  • IVI Murcia
  • IVI Vigo
  • Instituto Valenciano de Infertilidad, IVI Alicante
  • Vida Recoletas Sevilla

Registry information

Official study title

Evaluation of Induced Endometrial Injury in the Subsequent IVF Cycle.

Important dates

Study start
2013
Primary completion
2022
Study completion
2022
First posted
Oct 7, 2013
Registry last updated
Jan 11, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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