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OpenTrials
Completed

NCT Number: NCT03953859

Embryo DNA Repair Capacity Project

The mail aim of the present study is to use molecular methods to analyze the ability of human preimplantation embryos to repair their DNA

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

21 year–42 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Reproductive Medicine Assoicates of New Jersey

Basking Ridge, New Jersey, 07920, United States

About this study

The main aim of the present study is to investigate the DNA repair pathways of preimplantation embryos, examining the events that take place following induction of a DSB at a unique targeted site. The investigators aim to address questions concerning the functionality of the DNA repair mechanism(s) in developing embryos, before and after genome activation.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • gamete donors: be at least 21 years of age, in good health and eligible to donate their games through the standard gamete donation programs
  • IVF couples: any couples proceeding with a routine IVF cycle

Exclusion criteria

  • less than 21 years of age
  • inability to provide informed consent

Treatment and study plan

double strand break

Genetic

an induction of a double strand break will be made in the embryos generated for this research and the repair mechanism observed

Primary outcomes

  1. repair of double strand break in DNA

    Time frame: up to 12 days

    targeted deep sequencing to identify the presence of the double strand break in the DNA and subsequent repair ability of the embryo

Sponsors and collaborators

Lead sponsor

Reproductive Medicine Associates of New Jersey

Other

Registry information

Official study title

Investigation of Cellular DNA Repair Capacity in Human Preimplantation Embryos

Important dates

Study start
2019
Primary completion
2020
Study completion
2021
First posted
May 17, 2019
Registry last updated
Jan 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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