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Completed

NCT Number: NCT00663520

Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women

The purpose of this study is to determine if women with chest pain and "clean" heart blood vessels have impaired blood flow to the heart due to problems with the small blood vessels that provide blood and oxygen to the heart. Impairment in the small blood vessels will be tested using ultrasound pictures of the heart, called myocardial contrast echocardiography. Since these small blood vessels are not seen in a coronary angiogram, which is an x-ray of the heart vessels using a dye containing iodine injected in the heart vessels, the problem may remain undiagnosed in women until the heart muscle becomes severely damaged.

A second purpose is to identify if there is a common trait in the population of women with this tiny blood vessel dysfunction, which will be investigated by checking blood levels of certain chemical and hormones related to heart disease. Finally, we would like to investigate the relationship between depression and stress, and heart disease. We will do this by measuring cortisol (a hormone that serves as a measure of stress) and administering questionnaires that help to identify depression and stress.

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Key information

Conditions

Microvascular Dysfunction Cardiovascular Diseases Chest Pain Heart Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

45 year–75 year

Sex eligibility

Female

Study type

Observational

Primary location

Oregon Health and Science University

Portland, Oregon, 97239, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women 45 to 75 years of age

Exclusion criteria

  • Pregnancy
  • Allergy to any component of the drugs: Definity®. Dipyridamole Aminophyllin or Iodine.
  • Known coronary heart disease, significant valvular disease (valvular stenosis or insufficiency greater than moderate) left ventricular systolic dysfunction, congenital heart disease or cardiac shunt, pulmonary hypertension, moderate or severe asthma.
  • Inability to reach the patient by mail, fax, e-mail or phone
  • Active infection
  • Malignancy
  • Uncontrolled hypertension
  • Smoking
  • Severe asthma
  • Kidney disease

Treatment and study plan

Primary outcomes

  1. Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women

    Time frame: 2008-2014

    Data collection

Sponsors and collaborators

Lead sponsor

Oregon Health and Science University

Other

Registry information

Acronym: MVD

Important dates

Study start
2008
Primary completion
2014
Study completion
2014
First posted
Apr 22, 2008
Registry last updated
Apr 18, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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