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Completed

NCT Number: NCT00407004

Elimination of Albumin-Bound Substances by MARS and Prometheus

This trial compares the efficacy of two artificial liver support systems, MARS (Molecular Adsorbents Recirculating System) and Prometheus (FPSA, Fractionated Plasma Separation and Adsorption), in removing albumin-bound substances such as bilirubin, bile acids, and cytokines.

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Key information

Conditions

Liver Failure Acute-On-Chronic Liver Failure Digestive System Diseases Hepatic Insufficiency Liver Diseases Liver Failure, Acute

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of Graz

Graz, A-8036, Austria

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • consecutive patients with acute-on-chronic liver failure (severe deterioration of chronic liver disease) unresponsive to standard medical treatment for >=48 hours

Exclusion criteria

  • arterial hypotension
  • extrahepatic malignancy

Treatment and study plan

MARS (Molecular Adsorbents Recirculating System)

Device

Prometheus (FPSA, Fractionated Plasma Separation and Adsorption)

Device

Primary outcomes

  1. serum levels of albumin-bound substances

Secondary outcomes

  1. plasma clearance of albumin-bound substances

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Collaborators

  • Fresenius Medical Care North America

Registry information

Official study title

Effect of Extracorporeal Liver Support by MARS and Prometheus on Albumin-Bound Substances in Acute-on-Chronic Liver Failure

Important dates

Study start
2003
Study completion
2004
First posted
Dec 4, 2006
Registry last updated
Dec 4, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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