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Active, Not Recruiting

NCT Number: NCT06304415

Elevated Lipoprotein(a) in Hospital Staff

The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Hypercholesterolemia Cardiovascular Diseases Dyslipidemias Hyperlipidemias LIPOPROTEIN TYPES--Lp SYSTEM Lp(a) HYPERLIPOPROTEINEMIA Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

21 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinical Trials & Research Unit

Singapore, 529889

About this study

The objective of this study is to investigate the prevalence of elevated lipoprotein(a) concentrations and distribution of lipoprotein(a) in a working general population. This is a prospective study investigating the association of lipoprotein(a) with cardiovascular markers and outcomes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any healthcare workers working in healthcare settings (regardless of PHI and/or private setting) aged 21 and above OR family member such as father, mother, siblings, grandparents, spouse and children aged 12 and above of recruited staff with high Lpa ≥120nmol/l
  • Study team members can also be recruited because we are trying to find the prevalence of elevated Lp(a)

Exclusion criteria

  • Inability to provide informed consent.
  • Pregnant women.
  • Prisoner

Treatment and study plan

Primary outcomes

  1. Distribution and prevalence of elevated Lipoprotein(a)

    Time frame: 3 years

    Investigate the distribution lipoprotein(a) and prevalence of elevated lipoprotein(a) concentrations in various ethnicities.

Secondary outcomes

  1. Correlation of lipoprotein(a) with cardiovascular outcomes

    Time frame: 10 years

    Observational study to assess the correlation of degree of elevation of lipoprotein(a) with cardiovascular outcomes prospectively.

  2. Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events

    Time frame: 10 years

    Assess the association of genetic variants of lipoprotein(a) with the measured lipoprotein(a) concentrations in various ethnicities, and prospectively assess the association of these genetic variants with cardiovascular outcomes

Sponsors and collaborators

Lead sponsor

Changi General Hospital

Other

Registry information

Official study title

Investigating The Prevalence and Clinical Significance of Elevated Lipoprotein(a) Blood Levels in Hospital Staff

Acronym: LPACO

Important dates

Study start
2024
Primary completion
2035
Study completion
2036
First posted
Mar 12, 2024
Registry last updated
Mar 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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