Electrostimulation Study for Ocular Graft vs. Host Disease

The trial is to test whether transcutaneous electrical stimulation (TES) may be an effective new type of non-invasive treatment for patients who are diagnosed with chronic ocular Graft-vs-Host Disease. Such a treatment can potentially decrease the need for the patients to apply eye drops frequently, repair the damage caused by chronic ocular Graft-vs-Host Disease, and improve the comfort of the eyes naturally.

Inclusion criteria

• Diagnosis of chronic ocular graft vs. host disease (oGVHD) (ICCGVHD criteria probable or definite)
• OSDI score of 22 or higher
• NEI corneal staining score (or modified NEI score) of 2 or higher.

Exclusion criteria

• Patients with any open wound on the eyelid.
• Patient with any active cornea ulcer, dacryocystitis, hordeolum, filamentary keratitis, uveitis, retinal detachment, uncontrolled glaucoma or other active pathology per PI's discretion.
• Patient with a pacemaker or ICD.
• Patient currently pregnant or with a potential to be pregnant during the study.
• Patient undergoing any ocular surgical procedure (including intravitreal injections) within the past 3 months.
• Patient undergoing any systemic surgical procedures within 2 months.
• Patient undergoing any non-surgical eyelid procedure such as punctal plugs or punctal cautery within 1 month of study initiation.
• Patients on cytotoxic agents, drugs that inhibit peripheral nerve regeneration (i.e. Gabapentin, Nicotine), radiation therapy, or any other therapy per PI's discretion.
• Patients undergoing immunosuppression regimen change within 1 month of study initiation and/or during the study period.
• Patient who wears contact lens of any kind