Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information

The role of the basal ganglia in the processing of information with emotional or motivational content has been demonstrated by several lesion and functional imaging studies in humans and animals. Deep brain stimulation surgery provides an opportunity to study these structures in humans in electrophysiological terms. The aim of this study is to investigate modifications in the electrophysiological activity of the subthalamic nucleus (STN) during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson's disease who have just undergone implantation of a deep brain stimulator in the STN.

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Key information

Conditions

Parkinson

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Rennes

Rennes, 35000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient with Parkinson's disease selected for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in accordance with the criteria established by Welter and colleagues (Welter et al., 2002);
Aged 18 years or above;
Written informed consent from the patient.

Exclusion criteria

Patient under a legal incapacity or with limited legal capacity;
Patient who has perioperative complications or postoperative confusion;
Patient displaying cognitive disturbances involving the early stages of speech processing (on the basis of an audiogram systematically conducted prior to surgery) ;
Patient displaying cognitive disturbances involving the early stages of face processing (on the basis of the Benton Facial Recognition Test (Benton, Hamsher, Varney, & Spreen, 1983) systematically administered prior to surgery);
Patient incapable of understanding the information given about the study, performing the tasks or providing informed consent.

Treatment and study plan

Measure of the electrophysiological activity of the subthalamic nucleus

Other

Local field recording of the subthalamic nucleus by mean of externalized electrodes in the immediate postoperative periode.

Primary outcomes

Electrophysiological activity of the subthalamic nucleus

Time frame: 5 days

Electrophysiological activity of the subthalamic nucleus will be measured during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson disease who have just undergone implatation of a deep brain stimulator in the subthalamic nucleus

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Official study title

Study of the Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information in Patients With Parkinson's Disease

Acronym: EMOPHYSIO

Important dates

Study start: 2011
Primary completion: 2015
Study completion: 2016
First posted: Feb 23, 2012
Registry last updated: Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed