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NCT Number: NCT06609200

Electro-Acupuncture for Obese Patients With Insulin Resistance

This clinical trial aims to evaluate the efficacy and safety of electro-acupuncture for obese patients with insulin resistance. 60 participants will be randomized and allocated to either the electro-acupuncture arm or the sham acupuncture arm.

Recruiting

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Key information

Conditions

Obesity Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nanyang Technological University Traditional Chinese Medicine Clinic

Singapore, 637551

Location status: Recruiting

Location contact

Zipan Lyu, Ph.D. candidate

CONTACT

[email protected]

88649477

linda Zhong, Ph.D.

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women aged between 21 and 65 years old
  • BMI ≥ 25 kg/m2
  • HOMA-IR ≥ 2.14, (HOMA-IR = fasting insulin (ųU/mL)* fasting glucose (mmol/L)/22.5)
  • Not receiving any other weight control measures or any medical and/or drug history in the last 3 months

Exclusion criteria

  • Diabetes mellitus
  • Treating with drugs that may affect insulin sensitivity
  • Changes 10% of usual body weight in the previous 6 months weight
  • Endocrine diseases, including thyroid disorder, pituitary disorder, sex gland disorder, etc.
  • Heart diseases, including arrhythmia, heart failure, and myocardial infarction, participants with pacemakers
  • Allergy and immunology diseases
  • Bleeding tendency
  • Pregnant or lactating women
  • Impaired hepatic or renal function
  • Stroke or unable to exercise

Treatment and study plan

Acupuncture needles

Device

The acupuncture needles and related equipment will have already received approval for routine Traditional Chinese Medicine (TCM) clinical practice in Singapore.

Primary outcomes

  1. delta HOMA-IR

    Time frame: From baseline to the end of treatment at week 8

    delta HOMA-IR = (end-of-treatment fasting insulin (ųU/mL)* end-of-treatment fasting glucose (mmol/L)/22.5) - (baseline fasting insulin (ųU/mL)* baseline fasting glucose (mmol/L)/22.5)

Secondary outcomes

  1. Body Mass Index (BMI)

    Time frame: From enrollment to the end of follow-up at week 16

    BMI = kg/m2

  2. Waist-to-hip ratio

    Time frame: From baseline to the end of follow-up at week 16

    The waist-hip ratio or waist-to-hip ratio (WHR) is the dimensionless ratio of the circumference of the waist to that of the hips.

Study contacts

Contact information is provided by the study sponsor or research team.

Linda Zhong, Assoc prof

CONTACT

[email protected]

+65 8864 9477

ZIPAN LYU

CONTACT

[email protected]

+65 88649477

Sponsors and collaborators

Lead sponsor

Nanyang Technological University

Other

Registry information

Official study title

Electro-acupuncture for the Obese Patient With Insulin Resistance: a Randomized Sham-controlled Clinical Trial

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Sep 24, 2024
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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