Skip to main content
OpenTrials
Completed

NCT Number: NCT01513486

Electrical Stimulation During Immobilization

In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Disuse Atrophy Immobilization Muscular Diseases Muscular Disorders, Atrophic Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Neuromuscular Electrical Stimulation

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre

Maastricht, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Aged from 18-35 years
  • 18.5 < BMI < 30 kg/m2

Exclusion criteria

  • Smoking
  • Performing regular resistance training in the previous 6 months
  • Hypertension (according to WHO criteria) [46] and/or cardiovascular disease
  • Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
  • Use of any prescribed medication
  • Type 2 diabetes mellitus
  • Any family history of thrombosis
  • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
  • Myocardial infarction within the last 3 years
  • Use of anti-coagulants

Treatment and study plan

immobilization

Behavioral

Primary outcomes

  1. muscle mass, muscle fiber size

    Time frame: three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Secondary outcomes

  1. muscle strength measured by quadriceps 1-Repetition Maximum by Leg Extension

    Time frame: three days before immobilization, and directly after immobilization (day of cast removal; day 6)

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

The Effects of Daily Neuromuscular Electrical Stimulation on Muscle Mass During Short-term One-legged Knee Immobilization in Healthy Young Men

Acronym: ESDIM

Important dates

Study start
2012
Primary completion
2012
Study completion
2013
First posted
Jan 20, 2012
Registry last updated
May 22, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.