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Completed

NCT Number: NCT04603755

Electrical Impedance Tomography: Collapse in Dependent Areas as a Predictor of Response to Prone Position Ventilation in COVID-19 Acute Respiratory Distress Syndrome

There are several clinical presentations of SARS-CoV-2 infection. Among the severe forms, pulmonary involvement with respiratory failure is common. Although severe lung involvement with SARS-CoV-2 meets the Berlin criteria for Acute Respiratory Distress Syndrome (ARDS), it differs from classic ARDS in that compliance (reflecting distensibility of the lung parenchyma) is frequently preserved.

If the interest of Electrical Impedance Tomography has been demonstrated in classical ARDS, this is not the case in ARDS with COVID-19.

However, the use of this technique in this particular patient population would make it possible to distinguish patients with severe hypoxemia linked to derecruitment from those without derecruitment, in whom hypoxemia is more likely to be linked to the loss of hypoxic vasoconstriction.

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Key information

Conditions

SARS-CoV Infection Acute Respiratory Distress Syndrome Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections RNA Virus Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Severe Acute Respiratory Syndrome Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital de la Timone, Marseille, France

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Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients admitted to the intensive care unit for SARS-CoV-2 ARDS
  • Under controlled invasive ventilation for less than 7 days

Exclusion criteria

  • Pneumothorax
  • Deformation of the rib cage
  • Contraindication to Electrical Impedance Tomography
  • Pregnant or breastfeeding woman

Treatment and study plan

electrical impedance tomography

Device

Electrical Impedance tomography recording during 5 minutes every day during 7 days

Primary outcomes

  1. Coefficient of correlation between the percentage of derecruitment of dependent areas (measured with Electrical Impedance Tomography) and the response to prone position

    Time frame: Up to 7 days

    The percentage of derecruitment of dependent areas will be measured every day with Electrical Impedance Tomography.

    The response to prone position will be assessed every day.

Sponsors and collaborators

Lead sponsor

Direction Centrale du Service de Santé des Armées

Other

Registry information

Acronym: COVIDEIT

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Oct 27, 2020
Registry last updated
Sep 16, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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