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NCT Number: NCT06967207

Electrical Impedance Tomography-Based Prognostic Model for ARDS

This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung injury, the investigators intend to establish a prognostic model that reveals lung injury and heterogeneity, enabling risk stratification and guiding individualized treatment.

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Key information

Conditions

Acute Respiratory Distress Syndrome (ARDS) Lung Diseases Lung Injury Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Ventilator-Induced Lung Injury

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Critical Care Medicine, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meet the new 2023 ARDS global definition;
  • Age 18-80 years

Exclusion criteria

  • Expected death within 24 hours of screening;
  • Metastatic cancer (active malignancy with distant metastases);
  • Severe psychiatric disorders;
  • Pregnancy or postpartum status;
  • Pneumothorax or moderate to large pleural effusion without adequate drainage;
  • Chronic respiratory failure;
  • Patients with pulmonary embolism or pulmonary hypertension;
  • Heart failure patients: EF <50% or NYHA class III or IV;
  • Patient/family refusal to participate;
  • Participation in another interventional trial within 3 months prior to enrollment

Treatment and study plan

Not applicable- observational study

Other

Not applicable- observational study

Primary outcomes

  1. 28-day mortality rate

    Time frame: From date of study enrollment (Day 0) until Day 28

Secondary outcomes

  1. ICU mortality rate

    Time frame: From ICU admission to discharge, up to 24 weeks

  2. 60-day all-cause mortality rate

    Time frame: 60 days post-enrollment

  3. 90-day all-cause mortality rate

    Time frame: 90 days post-enrollment

  4. Duration of mechanical ventilation (days)

    Time frame: From intubation to successful extubation, up to 28 days

  5. Ventilator-free days (VFDs) at 28 days

    Time frame: 28 days post-enrollment

  6. ICU length of stay (days)

    Time frame: From ICU admission to discharge, up to 24 weeks

  7. Hospital length of stay

    Time frame: From hospital admission to discharge, up to 24 weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaojing Zou Zou

CONTACT

[email protected]

84+13995518630

Sponsors and collaborators

Lead sponsor

XiaoJing Zou,MD

Other

Registry information

Official study title

Electrical Impedance Tomography-Based Prognostic Model for ARDS: A Multicenter, Prospective, Observational Study

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
May 13, 2025
Registry last updated
May 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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