Elbasvir/Grazoprevir (EBR/GZR) and Sofosbuvir (SOF) With and Without Ribavirin (RBV) in Cirrhotic Subjects With Chronic Hepatitis C Virus (HCV) Genotype 3 (GT3) Infection (MK-5172-083)

Inclusion criteria

• has HCV RNA (>= 10,000 IU/mL in peripheral blood) at screening
• has documented HCV GT3 (with no evidence of non-typeable or mixed GT infection)
• has compensated cirrhosis of the liver
• has liver imaging within 6 months of Day 1 with no evidence of hepatocellular carcinoma (HCC)
• is either HCV TN or TE (i.e., has documented prior virologic failure or intolerance to peg-interferon/ribavirin)
• is otherwise healthy as determined by medical history, physical examination, electrocardiogram (ECG), and clinical laboratory measurements
• has compensated cirrhosis of the liver
• is TN or TE (i.e., documented prior virologic failure or intolerance to peg-interferon/ribavirin)
• is not of reproductive potential, or agrees to not impregnate a partner or become pregnant for at least 2 weeks prior to the first dose of study drug, and for 7 months after the final dose of study drug (or longer if dictated by local regulations)

Exclusion criteria

• has previously received one or more doses of a direct-acting antiviral (DAA)
• has evidence of decompensated liver disease
• is coinfected with hepatitis B (hepatitis B surface antigen [HBsAg] positive)
• has a recent (within 5 years) history of malignancy or is under evaluation for HCC or other suspected malignancy
• is currently or has participated (within past 30 days) in a study with an investigational compound
• has clinically-relevant drug or alcohol abuse within the past 12 months of screening
• is a female and is pregnant or breast-feeding
• is a male whose female partner is/are pregnant
• has any of the following:
• organ transplants
• poor venous access
• history of gastric surgery or malabsorption disorder
• current or history of clinically significant cardiac abnormalities or dysfunction
• chronic pulmonary disease
• hemoglobinopathy
• history of hospitalization within 3 months prior to enrollment
• medical or surgical condition that may result in need for hospitalization during the course of the study
• any condition requiring, or likely to require, chronic systemic administration of corticosteroids, tumor necrosis factor (TNF) antagonists, or other immunosuppresant drugs during the course of the study
• any condition, prestudy laboratory or ECG abnormality, or history of any illness, which could confound results of the study or pose additional risks in administering study drugs in the opinion of the investigator
• has a life-threatening serious AE (SAE) during the screening period
• has evidence of history of chronic hepatitis not caused by HCV