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Completed

NCT Number: NCT05469191

Eight-week Effect of the Sit-to-stand Test on Muscle Architecture.

An 8-week intervention of the sit-to-stand test (STS) of 5 and 10 repetitions will be performed to two randomly selected groups to compare its effect on the muscle architecture of the vastus lateralis muscle.

H1: 10 STS significantly modifies vastus lateralis muscle architecture in adults compared to 5STS and the control group.

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Key information

Conditions

Quality of Life Arquitecture Muscle Quality Muscle

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidad San Sebastián, sede Valdivia.

Valdivia, 50900000, Chile

About this study

Participants will be required to attend the laboratory for a first familiarization visit, where descriptive, biometric, and medical variables will also be evaluated. In addition, during this first familiarization session, it will be previously determined if the participants present any exclusion criteria and their muscle architecture will also be evaluated. After the familiarization session and the participants have signed the informed consent form, they will be randomly assigned to a 5 STS, 10 STS, or control group. Each group (exception of the control group) will be asked to perform three times a week one of the STS modalities assigned to them for 8 weeks, to ensure that the test is completed correctly and also to maintain the planning, the evaluator will be connected virtually with the participants, where rest times will be controlled and a fatigue perception scale will be performed at the end of each session, which will allow controlling the process each session. Subsequently, participants will be asked to attend the laboratory to re-evaluate their architectural parameters ( pennation angle, fascicle length, and muscle thickness) of the quadriceps muscle, one week after performing the intervention.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults, over 18 years of age.
  • They must have signed the informed consent form.
  • Who can perform the STS.
  • In case of suffering from a chronic non-communicable disease, that it is under control.

Exclusion criteria

  • Inability to perform the STS.
  • Hypertension (>200/110 mmHg).
  • Acute neuromuscular or joint injury.
  • Who have suffered a stroke in the last 6 months.
  • Who have suffered a myocardial infarction or fracture in the last 6 months.
  • Terminally ill.
  • People who practice a sport professionally.

Treatment and study plan

Group 5 STS

Other

For 8 weeks, 3 times per week and 3 sets of 5 repetitions during the first month, then 5 sets of 5 repetitions during the second month.

Between each repetition, there will be a rest of 30 to 60 seconds approximately.

Group 10 STS

Other

For 8 weeks, 3 times per week and 3 sets of 10 repetitions during the first month, then 5 sets of 10 repetitions during the second month.

Between each repetition, there will be a rest of 30 to 60 seconds approximately.

Primary outcomes

  1. Change in the pennation angle of the vastus lateralis muscle.

    Time frame: Before, 1 week completion of the intervention.

    Calculated as the angle of insertion of the muscle fiber fascicles into the deep aponeurosis, measured with a linear probe in B-mode.

  2. Change in the length of the fascicle of the vastus lateralis muscle

    Time frame: Before, 1 week after completion of the intervention.

    is calculated by measuring the length of the fascicular pathway between the superficial and deep aponeuroses,measured with a linear probe in B-mode.

  3. Change in vastus lateralis muscle thickness

    Time frame: Before, 1 week after completion of the intervention.

    Muscle thickness will be determined as the distance between the superficial aponeurosis to the deep aponeurosis, measured with a linear probe in B-mode.

  4. Change in muscle quality index (MQI)

    Time frame: Before, 1 week after completion of the intervention.

    Was calculated using two different formulas: one proposed by Takai et al. And one by Fragala et al. The "Takai formula" considers the time required to perform ten repetitions of the sit-to-stand test, while the "Fragala formula" uses the time required for five repetitions: MQI = ((leg length x chair height) x body mass x gravity x 10/ Time STS). Both calculations consider the length of the leg in meters, the height of the chair used in the test, body mass in kilograms, acceleration due to gravity (9.81 m/s^2), and a fixed constant of 10.

Secondary outcomes

  1. Change in STS mean velocity (m· s-1), STS mean force (N), STS mean power (W), and STS relative power (W·Kg-1)

    Time frame: Before, 1 week after completion of the intervention.

    The STS mean velocity (m· s-1), STS mean force (N), STS mean power (W), and STS relative power (W·Kg-1), were calculated with the formulas proposed by Alcazar et al. The formulas are as follows:

    • STS mean velocity = [0.5 x Height - Chair height] / Five STS time × 0.1]
    • STS mean force = 0.9 x g x Body mass
    • STS mean power = Body mass x 0.9 x g x [Height x 0.5 - Chair height / Five STS time × 0.1]
    • Relative STS mean power = 0.9 x g x Height [ 0.5 x Chair height] / Five STS time × 0.1]

Sponsors and collaborators

Lead sponsor

Universidad de Granada

Other

Registry information

Official study title

Effect of the Sit to Stand Test on Muscle Architecture After Eight Weeks.

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Jul 21, 2022
Registry last updated
Mar 2, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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