Eicosapentaenoic Free Fatty Acid and Fecal Calprotectin in Inflammatory Bowel Diseases

Inclusion criteria

• Age ranged between18 and 80 years.
• Patients with Ulcerative Colitis (diagnosed on the base of clinic, endoscopic and histologic criteria) in clinical remission (SCCAI = 0) from at least 3 months and in stable therapy (without therapeutic modifications in the three previous months) with 5-ASA, immunomodulators and/or biologics.
• Patients affected by Crohn's Disease (diagnosed on the base of clinic, endoscopic and histologic criteria) ) in clinical remission (CDAI < 150) from at least 3 months and in stable therapy (without therapeutic modifications in the three previous months) with 5-ASA, immunomodulators and/or biologics.
• Fecal calprotectin at baseline > 150 μg/g.

Exclusion criteria

• Patients affected by Ulcerative Colitis and Crohn's Disease respectively with a SCCAI ≥ 1 and a CDAI ≥150.
• Patients on steroid therapy.
• Patients in therapy wih warfarin or other anticoagulants.
• Known or supposed ipersensitivity to eicosapentaenoic acid/omega 3.
• Women in fertile age which refuse to use contracceptives specified in the study (oral contraception, IUD) and breastfeed women.
• Patients with severe clinical conditions which the investigator consider to controindicate patient partecipation at the study.
• Therapy modifications and/or assumption of sperimental therapies within three months before the study inclusion.
• Patients unable to follow protocol procedures and to sign the informate consent.