Egg Study With Peripheral Arterial Disease

Given the hypotheses proposed, if either of the first two predictions prove to be positive, they will help encourage directive efforts to be made toward effective nutrition messages for egg consumption in the peripheral arterial disease and the healthy population. If the last prediction is positive, while least favourable, it will still establish important information to assist the industry in their efforts toward establishing population-specific nutrition messaging.

Inclusion criteria

• Presence of peripheral arterial disease including those with claudication as defined by an ankle brachial index of ≤ 0.90 or asymptomatic carotid stenosis of > 50%; or who have had a previous intervention for peripheral arterial disease;
• Male or female, > 40 years of age;
• Willing to comply with the protocol requirements;
• Willing to provide informed consent;
• Stable medication profile with no changes anticipated for the duration of the proposed study schedule (8 weeks);
• Participants having completed the Flax Study are eligible to participate if their completion has been more than 3 months.

Exclusion criteria

• Renal failure requiring dialysis;
• Diabetes, requiring diabetic medication; Participants with diabetes who do not require diabetic medication and have good glycemic control will be eligible for participation in the study. Participant with elevated fasting blood glucose levels and glycated hemoglobin above 'standard of care' at baseline will not proceed with the study;
• Hyperlipidemia as defined by a cholesterol of >4.1 mmol/L (as per the National Cholesterol Education Program Adult Treatment Panel III, (NCEP ATP III) guidelines;
• Hormone replacement therapy;
• Inability to adhere to a regular diet;
• Habitual egg intake of 5 or more eggs per week;
• History of gastrointestinal reactions or allergies to eggs;
• Daily consumption of omega-3 supplements.