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Completed

NCT Number: NCT00260442

Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy

The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.

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Key information

Conditions

Sarcopenia Atrophy Cardiovascular Disease Cardiovascular Diseases Inflammation Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

50 year–69 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Texas A&M University

College Station, Texas, 77843, United States

About this study

The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12 weeks of resistance exercise training for the purpose of inducing skeletal muscle hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a double-blind design to test the hypothesis that dietary cholesterol is essential for skeletal muscle hypertrophy. If so proven, this will confirm a very strong association between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women (age 60-69). The current proposal is using a randomized double-blind, placebo controlled design to provide the most conclusive evidence that dietary cholesterol plays an essential role in skeletal muscle hypertrophy.

The secondary objective of this proposal is to test the hypothesis that increased dietary cholesterol consumption in the context of an exercise program does not alter blood cholesterol concentrations or other cardiovascular risk factors.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • men and women aged 50-69
  • able to perform exercise testing and training

Exclusion criteria

  • blood pressure > 160/100
  • cardiac arrhythmias
  • cancer
  • hernia
  • aortic aneurysm
  • kidney disease
  • lung disease
  • total cholesterol > 240 mg/dl or < 160 mg/dl
  • current use of cholesterol lowering medications
  • actively participating in >1 hour per week of resistance training

Treatment and study plan

Resistance training

Behavioral

12 weeks, 3 times a week whole body resistance training

Sedentary

Behavioral

Absence of physical activity

Primary outcomes

  1. Primary: Strength and muscle gain (DEXA)

    Time frame: after 12 weeks of resistance training

Secondary outcomes

  1. Secondary: Blood lipids, inflammatory markers, blood pressure

    Time frame: after 12 weeks of resistance training

Sponsors and collaborators

Lead sponsor

Texas A&M University

Other

Registry information

Important dates

Study start
2005
Primary completion
2008
Study completion
2018
First posted
Dec 1, 2005
Registry last updated
Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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