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OpenTrials
Completed

NCT Number: NCT05182814

Efficacy Testing of Collagen Drink on Skin Beauty and Sleep Aid

To assess Collagen Drink on skin condition and sleep quality improvement

Completed

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Key information

Conditions

Skin Condition Mental Disorders Nervous System Diseases Parasomnias Skin Diseases Skin and Connective Tissue Diseases Sleep Disturbance Sleep Wake Disorders

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chia Nan University of Pharmacy ＆ Science

Tainan, 71710, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults aged above 20 years old

Exclusion criteria

  • Subject who is not willing to participate in this study.
  • Patients with diseases of the skin, liver, kidney.
  • Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
  • Female who is pregnant or nursing
  • Constant drug use
  • Received facial laser therapy, chemical peeling or UV overexposure (>3 hours everyday) in the past 4 weeks.
  • Students taught by the PI

Treatment and study plan

Placebo drink

Dietary Supplement

Blank

Collagen Juice Drink

Dietary Supplement

Testing product

Other names: LISAVEI® Collagen Juice Drink

Primary outcomes

  1. The change of skin wrinkles

    Time frame: Change from Baseline skin wrinkles at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units

  2. The change of skin texture

    Time frame: Change from Baseline skin texture at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

  3. The change of skin collagen density

    Time frame: Change from Baseline skin collagen density at 8 weeks

    DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units

  4. The change of skin elasticity

    Time frame: Change from Baseline skin elasticity at 8 weeks

    Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units

  5. The change of skin L* value

    Time frame: Change from Baseline L* value at 8 weeks

    Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100

  6. The change of sleep quality

    Time frame: Change from Baseline sleep quality at 8 weeks

    Self-assessment questionnaire was utilized to survey sleep quality.

  7. The change of AGEs of blood

    Time frame: Change from Baseline AGEs at 8 weeks

    Venous blood was sampled to measure AGEs

  8. The change of TIMP-1 of blood

    Time frame: Change from Baseline TIMP-1 at 8 weeks

    Venous blood was sampled to measure TIMP-1

  9. The change of desmosine of blood

    Time frame: Change from Baseline desmosine at 8 weeks

    Venous blood was sampled to measure desmosine

Secondary outcomes

  1. The change of skin melanin index

    Time frame: Change from Baseline skin melanin index at 8 weeks

    Soft Plus was utilized to measure skin melanin index. Units: arbitrary units

  2. The change of skin pores

    Time frame: Change from Baseline skin pores at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units

  3. The change of skin a* value

    Time frame: Change from Baseline skin a* value at 8 weeks

    Chroma Meter MM500 was utilized to measure skin a* value. Units: arbitrary units

  4. The change of skin hydration

    Time frame: Change from Baseline skin hydration at 8 weeks

    Corneometer® CM825 was utilized to measure skin hydration. Units: arbitrary Corneometer® units 0-120

  5. The change of transepidermal water loss

    Time frame: Change from Baseline transepidermal water loss at 8 weeks

    Tewameter® TM300 was utilized to measure skin hydration. Units: g/hm²

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jan 10, 2022
Registry last updated
Jun 13, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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