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OpenTrials
Completed

NCT Number: NCT04266405

Efficacy Testing of Collagen and Zhuyin Drinks

To assess collagen and zhuyin drink on skin & body condition improvement

Completed

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Key information

Conditions

Skin Condition Skin Diseases Skin and Connective Tissue Diseases

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chia Nan University of Pharmacy ＆ Science

Tainan, 71710, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults aged above 20 years old

Exclusion criteria

  • Subject who is not willing to participate in this study.
  • Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history).
  • Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
  • Female who is pregnant or nursing or planning to become pregnant during the course of the study.
  • Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
  • Vegetarian
  • Subjects who have large spots (area >3 square centimeter) or abnormal acne.

Treatment and study plan

Placebo drink

Dietary Supplement

consume 1 bottle (50 mL) per day for 28 days

Collagen Cubilose Drink

Dietary Supplement

consume 1 bottle (50 mL) per day for 28 days

Primary outcomes

  1. The change of skin moisture

    Time frame: Change from Baseline skin moisture at 4 weeks

    Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

  2. The change of skin wrinkles

    Time frame: Change from Baseline skin wrinkles at 4 weeks

    VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units

  3. The change of skin collagen density

    Time frame: Change from Baseline skin collagen density at 4 weeks

    DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units:Intensity score

  4. The change of TEWL

    Time frame: Change from Baseline TEWL at 4 weeks

    Tewameter® TM 300 was utilized to measure TEWL. Units: g/h/m2

  5. The change of skin brightness

    Time frame: Change from Baseline skin brightness at 4 weeks

    Glossymeter GL 200 was utilized to measure skin brightness. Units: arbitrary units

  6. The change of interleukin-6

    Time frame: Change from Baseline skin brightness at 4 weeks

    Venous blood was sampled to measure concentrations of interleukin-6.

  7. The change of interleukin-8

    Time frame: Change from Baseline skin brightness at 4 weeks

    Venous blood was sampled to measure concentrations of interleukin-8.

  8. The change of Tumor necrosis factor

    Time frame: Change from Baseline skin brightness at 4 weeks

    Venous blood was sampled to measure concentrations of Tumor necrosis factor.

  9. The change of Matrix metalloproteinase-1

    Time frame: Change from Baseline skin brightness at 4 weeks

    Venous blood was sampled to measure concentrations of Matrix metalloproteinase-1 .

  10. The change of metallopeptidase inhibitor 1

    Time frame: Change from Baseline skin brightness at 4 weeks

    Venous blood was sampled to measure concentrations of metallopeptidase inhibitor 1.

Secondary outcomes

  1. The change of skin texture

    Time frame: Change from Baseline skin texture at 4 weeks

    VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

  2. The change of skin pores

    Time frame: Change from Baseline skin pores at 4 weeks

    VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units

  3. The change of skin spots

    Time frame: Change from Baseline skin spots at 4 weeks

    VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units

  4. The change of red areas

    Time frame: Change from Baseline red areas at 4 weeks

    VISIA Complexion Analysis System was utilized to measure red areas. Units: arbitrary units

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Feb 12, 2020
Registry last updated
Dec 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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