Efficacy Study of Vx001 Vaccine in NSCLC Patients

Main Inclusion Criteria:

• Male or female ≥18 years of age;
• Documented stage IV NSCLC as defined by IASLC Lung Cancer Staging Project (7th edition) or recurrent stage I-III disease at least 6 months after resection or after the end of adjuvant chemotherapy or after standard locoregional treatment as defined by the American College of Chest Physicians;
• Patients treated with 4 cycles platinum based 1st line chemotherapy as defined by the American College of Chest Physicians (i.e. radiotherapy are not allowed except palliative radiotherapy of bone metastasis);
• Documented HLA-A*0201 positivity, as determined by a local laboratory;
• TERT-positive NSCLC, as assessed by a central laboratory; for this, availability of adequate tissue biopsy from the primary tumor, lymph nodes or distant metastases is a prerequisite;
• CR, PR, or SD according to RECIST 1.1 criteria after the completion of platinum-based first-line chemotherapy;
• ECOG performance status 0, 1;

Main Exclusion Criteria:

• Mixed small cell and NSCLC histologies;
• Patients with stage IV or recurrent NSCLC who have been previously treated with therapy other than platinum-based first-line chemotherapy;
• Prior treatment with cancer vaccines;
• Prior treatment with immunotherapy (e.g., interferons, interleukins, TNF, or biological response modifiers, such as GM-CSF etc) within four weeks prior to randomization;
• Prior treatment with hormone (including corticosteroids) within 2 weeks prior to randomization;
• Prior treatment with any investigational drugs, within 4 weeks prior to randomization;
• Patients with brain metastases;