Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis

30 women aged 18-45 diagnosed with Provoked localized Vulvodynia will be included. 10 women will use topical Nifedipine cream 0.2% 4 times a day for 6 weeks (except for menstrual period). 10 other women will use topical Nifedipine cream 0.4% 4 times a day for 6 weeks (except for menstrual period).

10 women will be a control group and will use a placebo cream. The study will be randomized and double blind. Participants will be examined before starting the treatment, at the end of the treatment and 3 months after completion the treatment. A special detailed questionnaire has been prepared in three languages and will be used to compare dyspareunia and associate variables between the groups.

The Q-tip tests will be performed and findings will be drawn in each examination. Differences between the groups will be examined, and uni- and multi-variate analysis will be performed.

Inclusion criteria

• Women diagnosed with vestibulitis according to Friedrich's criteria:

• Severe pain with vestibular touch or attempted vaginal entry.
• A positive Q-tip test: pain produced by touching the vestibule with a cotton tipped applicator.
• Physical findings limited to varying degree of vestibular erythema.
• Non-pregnant women aged 18-45.
• Women use effective contraception and are not interested in becoming pregnant during the study period.
• No known Nifedipine allergy.
• No medical diseases.

Exclusion criteria

• Women who have undergone vestibulectomy.
• Active vaginal or pelvic infection.
• A medical disease uch as Diabetes, immune suppression.