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OpenTrials
Completed

NCT Number: NCT00232674

Efficacy Study of the Effect of Budesonide on Emphysema

To assess the effect of up to 4 years treatment with budesonide on progression of emphysema in patients with Chronic Obstructive Lung Disease.

Completed

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Research Site

Gentofte Municipality, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical Chronic Obstructive Pulmonary Disease diagnosis
  • smoker

Exclusion criteria

  • No exacerbation within the last 30 days
  • no long term use of oral corticosteroids

Treatment and study plan

Pulmicort (budesonide) Turbuhaler

Drug

Primary outcomes

  1. The primary variable in the study was change in lung density measured by Computed Tomography annually.

Secondary outcomes

  1. Decline in lung Function (FEV1) and exacerbation rate were measured biannually and decline in diffusion capacity (TLCO) annually.

Sponsors and collaborators

Lead sponsor

AstraZeneca

Industry

Registry information

Official study title

The Effect of Inhaled Corticosteroids on the Development of Emphysema in Smokers Assessed by Computed Tomography (CT).

Important dates

Study start
1999
Study completion
2004
First posted
Oct 5, 2005
Registry last updated
Jan 24, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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