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Completed

NCT Number: NCT02070679

Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography

The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.

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Key information

Conditions

Stable Angina Angina Pectoris Angina, Stable Angina, Unstable Cardiovascular Diseases Chest Pain Heart Diseases Myocardial Ischemia Neurologic Manifestations Non ST Segment Elevation Myocardial Infarction Pain Pathological Conditions, Signs and Symptoms Post MI Signs and Symptoms Unstable Angina Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Seyyed-al-Shohada Heart Center, UMSU, Urmia, West Azerbaijan Province, Iran

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients whon have either stable coronary artery disease (CAD) or recent acute coronary disease (ACS) and are scheduled for coronary angiography.
  • Patients who have eGFR ≤60 ml/min/1.73 m2

Exclusion criteria

  • Allergy to contrast media
  • Cardiogenic shock
  • Pulmonary edema
  • Overt cardiac failure or left ventricular ejection fraction ≤ 30%
  • Acute kidney injury
  • The history of receiving contrast media for any medical diagnostic or therapeutic procedures during previous 5 days
  • The history of dialysis
  • Being pregnant
  • Having recent acute myocardial infarction
  • Taking antioxidants and nephrotoxic drugs including NSAID and ACE-I on previous 2 days

Treatment and study plan

Vitamin E

Drug

Other names: Alpha-tocopherol

Primary outcomes

  1. The development of CI-AKI in group receiving vitamin E compared with placebo

    Time frame: Within 72 hours after coronary angiography

Secondary outcomes

  1. Changes in the serum level of Cr and the amount of eGFR

    Time frame: Within 72 hours

Sponsors and collaborators

Lead sponsor

Urmia University of Medical Sciences

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Feb 25, 2014
Registry last updated
Jun 16, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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