Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate

Clomiphene and vit E each used in treatment of pco but they do so by different mechanisms.

Clomifene is in the selective estrogen receptor modulator (SERM) family of medication. It works by causing the release of gonadotropin-releasing hormone by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.

Vit E is used in treatment of pco due its anti-oxidant effect.

Inclusion criteria

• Patients will be diagnosed as having PCOS according to the Rotterdam criteria for diagnosis of PCOS
• Age between 18 and 39 years.
• Period of infertility >1 years.
• No treatment taken during the last 2 months.
• Patients who have previously received clomiphene citrate (CC) and being diagnosed as having CC resistance

Exclusion criteria

• History of pelvic surgery or infertility factor other than anovulation
• Endocrine disorders in the form of hypothyroidism or hyperthyroidism, hyperprolactinemia, and Cushing syndrome, as detected by history, examination, or investigations.
• Known cases of endometriosis (approved histologically), uterine anomaly or hydrosalpinx, retinitis pigmentosa and vitamin K deficiency.
• Consumption of vitamin and antioxidant supplementations in the last three-months before the trial start date.
• Male factor infertility (sperm count < 5 million per milliliter, normal morphology <4%).
• Elevated serum prolactin, T.S.H and F.S.H.
• Patients diagnosed with diabetes mellitus