Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease

Inclusion criteria

• Age · Patients 18 years of age or older
• Ocular Health

• Chronic corneal epithelial disease with fluorescein staining score 6 by NEI grading scale or persistent corneal epithelial defect present for longer than 14 days despite standard treatment
• No objective clinical evidence of significant (> 50%) improvement/worsening of the epithelial disease in the last 14 days
• Epithelial disease refractory to conventional non-surgical treatments (e.g., preservative-free artificial tears, gels or ointments; discontinuation of preserved topical drops; anti-inflammatory therapy)
• If both eyes of subject meet the inclusion criteria, the eye with the higher fluorescein staining score will be enrolled to the study.
• Study Procedures

• Only patients who satisfy all Informed Consent requirements may be included in the study. The patient and/or his/her legal representative must read, sign and date the Informed Consent document before any study-related procedures are performed. The Informed Consent form signed by patients and/or legal representative must have been approved by the UIC IRB for the current study. Patients must have the ability and willingness to comply with study procedures.

Exclusion criteria

• Ocular Health

• Any active or suspected ocular infection (bacterial, viral, fungal or protozoal).
• History of any ocular surgery (including laser or refractive surgical procedures) in the study eye within the 3 months prior to study enrollment.
• Treatment with Oxervate in the study eye within 12 months of enrollment.
• Study Procedures

• Known hypersensitivity to one of the components of the study or procedural medications (e.g., fluorescein).
• Use of any investigational agent within 4 weeks of screening visit.
• Participation in another clinical study at the same time as the present study.
• Participants who are pregnant at the time of study enrollment.