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Completed

NCT Number: NCT04142801

Efficacy of the Memory Motivation (MEMO) Web Application Training

Memory, attentional, and behavioural symptoms are the clinical hallmarks of Neurocognitive disorders (NCD) such as Alzheimer's disease and related disorders. The World Health Organisation (WHO) guidelines for risk reduction of cognitive decline and dementia indicate that Cognitive training may be offered to older adults with normal cognition and with mild cognitive impairment to reduce the risk of cognitive decline and/or dementia. The use of Information and Communication Technologies (ICT) in the health domain is progressively expanding. The Alzheimer Innovation Association have developed MeMo (Memory Motivation) a free web application that can be used at home by patients.

The objective of the present study was to assess the effectiveness of employing the MeMo platform on cognitive performance in patients suffering from NCD.

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Key information

Conditions

Neurocognitive Disorders Mental Disorders

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CoBtek lab, Institut Claude Pompidou

Nice, 06100, France

About this study

The objective of this study is to evaluate the effectiveness of the MeMo cognitive training exercise platform in patients suffering from neurocognitive disorders. These exercises ,have been developed by the association Innovation Alzheimer and the CoBTeK research team, located with the Nice memory Center at the Institut Claude Pompidou. MeMo can be used freely at home by patients. More specifically, it is a randomized controlled study that aims to compare the evolution of activities cognition and behavior between patients not using these exercises, and patients using these exercises for 12 weeks, 4 sessions per week.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Outpatient consulting the Memory center
  • older than 60 years old
  • Mini Mental State examination score (MMSE) between 16 and 28 / 30
  • met the DSM 5 diagnoses of mild neurocognitive disorders (mild NCD) or major neurocognitive disorders (Major NCD).

Exclusion criteria

  • Patients not able to read and write French
  • presence of a hearing or major visual impairment
  • a history of premorbid mental retardation
  • had already used the MeMo application
  • were presently involved in structured memory training activities.

Treatment and study plan

MeMo web application

Device

The patient betwenn 2 consultation could use the application MeMo. MeMo is a web application that can thus be used on any web browser (computer or tablet). On tablet, the application can be installed on home screen to look like a native app, and used offline.

Control Group

Other

the patient have the classical follow up at the memory center (consultation)

Primary outcomes

  1. Change is being assessed with the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)

    Time frame: Base line, Week 12

    To score the IQCODE, add up the score for each question and divide by the number of questions. For the long IQCODE, divide by 26.

Secondary outcomes

  1. Change in attention is is being assessed with the DSST

    Time frame: Base line, Week 12

    Digit Symbol Substitution Test (attentional task)

  2. Change in frontal functioning is being assessed with the FAB

    Time frame: Base line, Week 12

    the Frontal Assessment Battery: Score 0 (healthy) - 18 (pathology)

  3. Change in behavior is being assessed with the NPI

    Time frame: Base line, Week 12

    Neuropsychiatric Inventory score 0 (healthy) - 134 (pathology)

  4. IA-C

    Time frame: Base line, Week 12

    Change in motivation is being assessed with theApathy inventory, clinician version score 0 (healthy)- 12 (pathology)

Sponsors and collaborators

Lead sponsor

Innovation Alzheimer

Other

Collaborators

  • Alzheimer's Association
  • Centre Hospitalier Universitaire de Nice
  • Université de Nice Sophia Antipolis

Registry information

Official study title

Efficacy of the Memory Motivation (MEMO) Web Application for Cognitive and Behavioral Training in Patients With Neurocognitive Disorders

Acronym: MeMo

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Oct 29, 2019
Registry last updated
Oct 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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