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Completed

NCT Number: NCT04485520

Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans

Papaya has effects on oral pathogenic microorganisms, it also has anticoagulant quality, amebicidal action, antimicrobial, bacteriostatic and antifungal activity on different bacteria, especially on Streptococcus mutans, this can be exploited in the dental area. The objective of the study was to determine the efficacy of Carica Papaya peel extract (suckling) as an inhibitor of Streptococcus Mutans in students of the dental faculty of the National University of Caaguazú in 2018.

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Key information

Conditions

Streptococcus, Other Specified Group Dental Deposits Dental Plaque Stomatognathic Diseases Tooth Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Facultad de Odontología Universidad Nacional de Caaguazú

Coronel Oviedo, International, 595, Paraguay

About this study

Specific objectives

  • To determine the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on Streptococcus Mutans by age and sex grouping.
  • To quantify the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on the growth of Streptococcus Mutans before, at 10 minutes and 8 days of use in the experimental group.
  • Quantify the inhibition of 0.12% Chlorhexidine Gluconate on the growth of Streptococcus Mutans before, after 10 minutes and 8 days of use in the control group.
  • Compare the count of Colony Forming Units (CFU) between both groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants that signed the informed consent

Exclusion criteria

  • allergic to carica papaya
  • ongoing medical or dental treatment that could interfere with the results.

Treatment and study plan

CARICA PAPAYA MOUTHWASH

Other

Each application was 10 ml. applied for 1 minute, once a day for 8 days

Chlorhexidine mouthwash

Other

Each application was 10 ml. applied for 1 minute, once a day for 8 days

Primary outcomes

  1. Number of Colony Forming units (Stage 1)

    Time frame: thorough study completion, an average of 24 hours

    Before Intervention

  2. Number of Colony Forming units (Stage 2)

    Time frame: 10 minutes after mouthwash use

    After Intervention

  3. Number of Colony Forming units (Stage 3)

    Time frame: 8 days after mouthwash use

    After Intervention

Sponsors and collaborators

Lead sponsor

Julieta María Méndez Romero

Other

Registry information

Official study title

Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans in Students of the Faculty of Dentistry in the Year 2018

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Jul 24, 2020
Registry last updated
Aug 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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