Faculty of Dentistry, MSA University
Giza, Giza Governorate, 12611, Egypt
Location contact
Khaled Abdelmonem, Master degree
CONTACT
khaled Abdelmonem, master degree
PRINCIPAL_INVESTIGATOR
NCT Number: NCT07382245
Early childhood caries is a major public health problem affecting preschool children worldwide. Silver Diamine Fluoride is a well-established non-invasive treatment for arresting caries; however, it causes black discoloration of treated lesions. Nano-Silver Fluoride has been introduced as an alternative that may arrest caries without discoloration.
This randomized clinical trial aims to compare the efficacy of Silver Diamine Fluoride and Nano-Silver Fluoride in arresting active dentin caries in primary teeth and to assess discoloration, post-operative pain, and parental satisfaction over a 12-month follow-up period.
Trial opening soon.
Get Notified3 year–5 year
All sexes
Interventional
Not applicable
Giza, Giza Governorate, 12611, Egypt
Khaled Abdelmonem, Master degree
CONTACT
khaled Abdelmonem, master degree
PRINCIPAL_INVESTIGATOR
This randomized clinical trial will be conducted on 30 children aged 3-5 years attending the outpatient clinic of Pediatric Dentistry, Faculty of Dentistry, Suez Canal University. Children with active dentin caries in primary molars will be randomly allocated into two groups: Silver Diamine Fluoride group and Nano-Silver Fluoride group.
Both materials will be applied topically without caries excavation. Clinical evaluation will be performed at baseline and at 1, 3, 6, 9, and 12 months using ICDAS criteria, visual and tactile examination, assessment of post-operative pain, discoloration through standardized photographs, and parental satisfaction questionnaires.
The primary outcome is caries arrest. Secondary outcomes include discoloration, pain, and parental satisfaction.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Chitosan (28,585 μg/ml), Silver (376.5 μg/ml) and Sodium fluoride (5028.3 μg/ml)
38% Silver Diamine Fluoride
Time frame: 1, 3, 6, 9 and 12 months
Arrest of caries assessed clinically by hardness of dentin using blunt periodontal probe and ICDAS criteria
Time frame: 1, 3, 6, 9 and 12 months
Assessment of color change using standardized pre- and post-operative photographs
Time frame: 1, 3, 6, 9 and 12 months
Presence or absence of pain assessed through parental interview
Time frame: 1, 3, 6, 9 and 12 months
Evaluation using a structured parental satisfaction questionnaire
Contact information is provided by the study sponsor or research team.
Khaled Abdelmonem Sayed Assistant Lecturer at Pediatric Dentistry Department, Master Holder
CONTACT
October University for Modern Sciences and Arts
Other
Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children: A Randomized Clinical Trial
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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