Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain

The purpose of this study is to compare the efficacy of selective COX-2 inhibitors{ etoricoxib vs celecoxib )in relieving orthodontic pain , after initial bonding and arch wire insertion.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Orthodontic Pain (D013850)

Age range

13 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Sharif Medical City Lahore

Lahore, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 13 to 30 years
Fully erupted permanent dentition excluding third molars
Mild crowding (0 -4mm)

Exclusion criteria

Active periodontitis
Deep cavities or large restorations
Previous dental extraction in less than 4 weeks before bonding
History of steroid use within last 6 weeks

Treatment and study plan

Celecoxib

Drug

Group A will be given Celecoxib 50mg once a day.

Etoricoxib (Treatment Group)

Drug

Group B will be given Etoricoxib 60mg once a day.

Primary outcomes

Pain intensity

Time frame: 1 year

Pain scores will be measured using a 10cm Visual Analogue Scale (VAS) , The Scale consists of a horizontal line anchored by two verbal descriptions where 0 represented '' No Pain '' and 10 represented ''Maximum Pain''. The Score is determined by measuring the distance from left end of the scale to the mark made by the participant.

Sponsors and collaborators

Lead sponsor

Sharif Medical Research Center

Other

Registry information

Official study title

Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain ;a Randomized Controlled Trial

Acronym: EOSCOX2

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2026
First posted: Apr 30, 2026
Registry last updated: Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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