Efficacy of Seated Exercise on Functional Capacity and Quality of Life in Patients With Leukemia During Chemotherapy Cycles

This study aims to evaluate the efficacy of seated exercise on functional capacity and quality of life in patients with leukemia during chemotherapy cycles Participants will receive efficacy of seated exercise on functional capacity and quality of life in patients with leukemia during chemotherapy cycles over a defined period. Outcomes will be assessed using Pulmonary function test, 6 min walk test and FACT- G questionnaire to determine improvements in quality of life in cancer patient rehabilitation special to diagnosed with leukemia.

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Key information

Conditions

Leukemia Hematologic Diseases Hemic and Lymphatic Diseases Neoplasms Neoplasms by Histologic Type

Age range

30 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

Cancer is a major public health that gives an economical burden on the patient and government. The incidence of different types of cell tumors are increasing nowadays. Although chemotherapy is given to kill cancer cells, it also damage normal cells and cause significant side effects while others may have more. Some CT side effects can be severe enough to require hospitalization effects. CT affects patients functional capacity and quality of life next to the cancer it self. This study is designed as randomized controlled trial to assess the impact of seated exercise on functional capacity and quality of life in patient with leukemia during chemotherapy cycles. participants will be recruited from National Cancer Institute.

The intervention protocol includes a-30 minutes seated exercise program three times a week with at least a one- day break between sessions for four weeks for the treatment group. Outcome measures will include maximum voluntary ventilation, 6 min walk test distance and FACT-G questionnaire before and after the exercise program. The program includes a five- minute warmup, 20 minutes of moderate-intensity repetitive motion exercise and a five- minute cool down.

Ethical considerations:

This study has been reviewed and approved by the Ethical Committee of Benha university. Written informed consent will be obtained from all participants or their legal guardians prior to treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male patients with age ranges from 30 to 40 years.
All patients in this study will be on chemotherapy from at least one cycle as a treatment of leukemia.
All patients will be hemodynamically stable.
Patients are ambulant.

Exclusion criteria

Lung cancer
History of any pulmonary disease.
Metastasis of lung , ribs and mediastinal structure.
Pulmonary pathology (e.g. acute respiratory distress syndrome, or exacerbation of chronic obstructive pulmonary disease).
Ruptured eardrum or any other condition of the ear.
Severe bronchospasm.
High peak air way pressure (barotraumas).
patients with marked elevated left ventricular end- diastolic volume and pressure.
patients with worsening haert failure signs and symptoms.

Treatment and study plan

Seated exercise

Behavioral

Participants in the intervention group will perform a structured seated exercise program during their chemotherapy cycles. The exercise program will consist of supervised, individualized seated exercises designed to improve functional capacity and quality of life. The exercise sessions will be performed according to the study protocol throughout the intervention period.

Each session will consist of a five-minute warm up, 20 minutes of moderate intensity repetitive motion exercises, and a five -minute cool-down. Functional outcomes will be assessed before and after the exercise program. including maximum voluntary ventilation , six-minute walk test distance, and FACT- G quesionnaire.

Primary outcomes

change in functional capacity

Time frame: Baseline and after 4 weeks of intervention

Functional capacity will be assessed by the six-minute walk test (6MWT) distance before and after the four week seated exercise programe.
change in quality of life

Time frame: Baseline and after 4 weeks of intervention

Quality of life will be assessed using the FACT-G questionnaire before and after the four week seated exercise programe

Secondary outcomes

Change in Maximum Voluntary Ventilation (MVV)

Time frame: Baseline and after 4 weeks of intervention

Change in Maximum Voluntary Ventilation (MVV) will be assessed before and after the four week seated exercise program

Sponsors and collaborators

Lead sponsor

Suez University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jul 31, 2026
Registry last updated: Jul 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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