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OpenTrials
Completed

NCT Number: NCT06030024

Efficacy of Repetitive Transcranial Magnetic Stimulation in Adult Attention Deficit Disorder

The purpose of the current open-lable study was to use low-frequency repetitive transcranial magnetic stimulation (rTMS) to improve the attention deficits in a sample of adult patients suffering from attention deficit disorder. Participants received 10 sessions of rTMS over Fz (located using the EEG 10-20 international system) and underwent assessments of their attentional capacity using the gradCPT task in an fMRI scanner, before and after the intervention. Other behavioral assessments of their attention symptoms have also been conducted.

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Key information

Conditions

Attention Deficit Disorder ADHD Attention Deficit Disorder with Hyperactivity Attention Deficit and Disruptive Behavior Disorders Mental Disorders Neurodevelopmental Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Brain Mapping Lab

Tehran, 1439957131, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal intelligence level (>90)
  • Diagnosis of ADD by a psychiatrist using the ADHD-RS-IV with Adult Prompts

Exclusion criteria

  • Scores of 21 or more on BDI and/or BAI
  • History of head trauma
  • History of a major psychological or neurological condition
  • Presence of metal in the head
  • History of seizures
  • Serious cardiovascular disease
  • Use of medications with an impact on cognitive functions during the treatment window (patients with a constant and stable dose were included)
  • Recent use of alcohol or substance abuse

Treatment and study plan

repetitive transcranial magnetic stimulation

Device

Magnetic pulses delivered to the Fz area of the brain in a low frequency (1 Hz) manner.

Primary outcomes

  1. Change in performance

    Time frame: Up to 10 days, i.e., before and after the completion of the 10 sessions of rTMS

    Shortened version (4 min) of the continuous go/no-go task: gradual-onset continuous performance task (gradCPT)

Secondary outcomes

  1. Change in self-report attention scores

    Time frame: Baseline, after 5 days of stimulation, after 10 days of stimulation; Range= 0-6; Higher scores represent worse outcome

    The 6-item ASRS-V1.1 Adult ADHD Self-Report

  2. Change in investigator-rated attention scores

    Time frame: Baseline, after 5 days of stimulation, after 10 days of stimulation; Range:0 - 54; Higher scores represent worse outcome

    Investigator-Rated Attention-Deficit Hyperactivity Disorder (ADHD) Rating Scale-IV (I-ADHD RS-IV) with adult prompts

Sponsors and collaborators

Lead sponsor

University of Tehran

Other

Registry information

Official study title

An Open-lable Investigation of the Effect of rTMS on Attention in an Adult Sample Suffering From ADD

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Sep 8, 2023
Registry last updated
Sep 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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