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OpenTrials
Completed

NCT Number: NCT01991119

Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation

the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cardiac and Vascular Center

Seoul, 135-710, South Korea

About this study

Atrial fibrillation is the most common arrhythmia requiring continuous therapy. Conversion to and maintenance of sinus rhythm is important. Propafenone and dronedarone has been used as treatment for maintenance of sinus rhythm after DC cardioversion. But there are no direct comparison study.

The purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a patient with persistent atrial fibrillation who received successful DC cardioversion

Exclusion criteria

  • prior amiodarone use
  • NYHA class III or IV heart failure
  • Left ventricular ejection fraction < 35%
  • second or third AV block
  • sick sinus syndrome
  • heart rate < 50 beat per minute
  • myocardiac infarction within 3 months
  • pregnant women
  • severe hepatic dysfunction
  • QT prolongation > 500ms or PR interval > 180ms
  • history of hypersensitivity for drug

Treatment and study plan

Propafenone

Drug

DRONEDARONE

Drug

Primary outcomes

  1. recurrence of atrial fibrillation

    Time frame: 6 month

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation After DC Cardioversion

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Nov 25, 2013
Registry last updated
Nov 25, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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