Efficacy of Pre-operative Prehabilitation in Patients With Limb Sarcoma

Inclusion criteria

• Age > or = 16 years old.
• Patient with a diagnosis of bone or soft-tissue sarcoma confirmed by the "Réseau de Relecture en Pathologie Sarcomateuse (RRePS)"
• Tumour localized in the lower or upper limb.
• Localized or metastatic disease (in case of metastatic disease, the optimal surgical treatment for the primary tumor must be performed).
• Indication of neoadjuvant treatment (radiotherapy and/or chemotherapy) according to the Multidisciplinary Concertation Meeting.
• Inclusion before the initiation or during neoadjuvant treatment. In both cases, surgery must be scheduled between 6 and 10 weeks after inclusion, to permit the completion of the surgical prehabilitation.
• Patient must provide written informed consent prior to any study-specific procedure. For minor patients, the holder(s) of parental authority must sign the informed consent and the patient's assent must be obtained.
• Patient affiliated to the French social security system.

Exclusion criteria

• Metastatic disease without optimal surgery planned of the primary tumour.
• Any disease or medical condition that could interfere with study procedure, or that could, according to the judgment of investigator, expose the patient to an unacceptable risk.
• Patient who has forfeited his/her freedom by administrative or legal award or who is under legal protection (curatorship and guardianship, protection of justice).
• Any psychological, familial, geographic or social situation preventing compliance with the medical monitoring and/or with study procedure.
• Pregnant or breastfeeding patient.