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Completed

NCT Number: NCT07190911

Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 COVID-19 (Covid-Smell)

The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.

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Key information

Conditions

COVID - 19 Ageusia Anosmia COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nervous System Diseases Neurologic Manifestations Nidovirales Infections Olfaction Disorders Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Sensation Disorders Signs and Symptoms Taste Disorders Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chu de La Guadeloupe

Pointe-à-Pitre, 97159, Guadeloupe

About this study

The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • SARS-CoV-2 infection suspect or confirmed
  • supported by CHU Guadeloupe
  • with brutal olfactory or taste loss
  • affiliated or beneficiary of a social security scheme
  • informed consent signed

Exclusion criteria

  • recent rhinosinusitis, less than 6 months
  • lingual pathology
  • communication disorder
  • Patients subject to a justice safeguard
  • Allergy to several spices that are part of the rehabilitation set
  • Pregnant or breastfeeding women
  • Absence of signed consent

Treatment and study plan

Olfactory rehabilitation consists of smelling a series of spices every day for 2 months

Other

Olfactory rehabilitation consists of smelling a series of spices every day for 2 months: vanilla, coffee, dill, thyme, cinnamon, cloves, lavender, coriander, light vinegar, mint, and cumin.

This rehabilitation is based on the protocols proposed by SFORL (French ORL society) and Oleszkiewicz et al.8

Allergies to certain spices will be noted at the start of the study:

  • in known allergy: change by another spice which belongs to the same chemical category.
  • in case of allergies to several scents: patient is not included in the study.
  • in case of allergy appearing during participation: clinical evaluation by ENT, change by another spice which belongs to the same chemical category.
  • in case of allergies to several scents occuring during participation: patient is excluded from the study.

Primary outcomes

  1. Taste and Smell Survey (TSS).

    Time frame: Baseline and 2 months

    Patients will have this auto evaluation scale at the inclusion (D0) and 2 month after inclusion (D60).

Secondary outcomes

  1. Sniffin' stick test :

    Time frame: 2 month

    The Sniffin' Stick Test assesses the sense of smell by measuring odor detection threshold, discrimination, and identification, and is used for diagnosing and monitoring olfactory disorders.

  2. Olfaction and taste evolution evaluated with a daily visual scale

    Time frame: Every day from inclusion to 2 months

    Visual analogue scale from 0 to 10 to assess dysosmia and dysgeusia, with 0 indicating normal function and 10 indicating complete deficit.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de la Guadeloupe

Other

Registry information

Official study title

Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 (Covid-Smell)

Acronym: COVID-SMELL

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Sep 24, 2025
Registry last updated
Oct 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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