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Completed

NCT Number: NCT00256048

Efficacy of Nasojejunal Enteral Feeding in Critically Ill Patients.

The purpose of this study is to determine if naso-jejunal feeding (feeding beyond the stomach) improves the efficacy of enteral feeding (feeding into the gut) in critically ill patients.

The study hypothesis is that in patients who fail to establish enteral feeding via the nasogastric route, introduction of nasojejunal feeding will lead to more effective enteral feeding than the current regime involving staged introduction of promotility agents.

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Key information

Conditions

Critically Ill Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Intensive Care Unit, Royal Melbourne Hospital, Grattan Street

Parkville, Victoria, 3050, Australia

About this study

The study examines the area of enteral feeding in critically ill patients. Current standard enteral feeding practice is via a nasogastric with the addition of promotility agents for patients who fail to absorb their enteral nutrition.

This study compares the efficacy of nasojejunal feeding feeding with nasogastric enteral feeding with the addition of promotility agents.

The duration of feeding will be determined by the patients nutritional requirements and their general condition. However the data will be collected for duration of enteral feeding, 28 days or ICU discharge whichever occurs first.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (18years or over) admitted to the ICU with an expected stay of more than 48 hours.
  • Patients commenced on enteral feeding via a nasogastric tube who fail to tolerate gastric feeding due to excessive gastric aspirate volumes.
  • Patients who consent or if the patient is incompetent, the next of kin, who consent, to inclusion in the study.

-

Exclusion criteria

  • patients less than 18 years of age.
  • Patients with known allergy to promotility agents, metoclopramide or erythromycin.
  • Patients with a contra indication to nasojejunal feeding. -

Treatment and study plan

Nasojejunal feeding

Procedure

Primary outcomes

  1. Efficacy of feeding

    Time frame: participants will be followed until death, discharge from ICU, commencement of oral or parental nutrition or 28 days post ICU admission

Secondary outcomes

  1. 1. To determine the incidence of complications with enteral feeding via nasogastric and nasojejunal routes.

    Time frame: participants will be followed until death, discharge from ICU, commencement of parental or oral nutrition or 28 days post ICU admission.

  2. 2. To assess the efficacy of current strategies for optimising enteral feeding efficacy.

    Time frame: participants will be followed until death, discharge from ICU commencement of oral or parental nutrition,or 28 days post ICU admission.

Sponsors and collaborators

Lead sponsor

Melbourne Health

Other

Registry information

Important dates

Study start
2003
Study completion
2005
First posted
Nov 21, 2005
Registry last updated
Apr 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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