Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal

STUDY DESIGN

• randomized,double blind, prospective, multicentric, parallel group, intent to treat trial
• Experiment duration: 3 days
• 2 visits (days 0 and 2)
• Evaluation of symptoms reduction
• Adverse events evaluation

Inclusion criteria

• Patients must be able to understand the study procedures, agree to participate and give written consent.
• Patients aged over 18 years of both sexes;
• Patients with clinical signs of flu and colds or other upper respiratory allergies;
• Patients with early signs and symptoms with time of evolution not more than 72 hours.

Exclusion criteria

• Patients treated with antibiotics
• Current treatment with immunosuppressants (eg.cyclosporine or methotrexate);
• Use of intranasal cromalin the week before inclusion;
• Use of decongestants or anti-histaminic (intranasal or systemic);
• Presence of any disease or anatomical abnormality that may difficult the data analysis ;
• Uncontrolled hypertension;
• Presence of respiratory symptoms for more than 14 days;
• History of abuse of drugs and alcohol;
• Presence of other concomitant pulmonary diseases;
• Hypersensitivity to any compound of investigational product