Barzilai University Medical Center
Ashkelon, Ashkelon District, 7830604, Israel
Location status: Recruiting
Location contact
Dr Arie Budovsky, PhD
CONTACT
Dr Leonty Green, MD
CONTACT
Recruiting
NCT Number: NCT03560583
Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.
Metoclopramide belongs to the antiemetic group, used for motion sickness and during early gestation for hyperemesis gravidarum.
The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation and result in increased oocyte retrival.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–54 year
Sex eligibility
Female
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Poor response according to "Bologna criteria"
Exclusion criteria
- Allergy to metoclopramide
- Prolactinemia
- Women treated with dopamine agonists
Treatment and study plan
Metoclopramide
DrugMetoclopramide 10 mg BID
Placebo oral tablet
DrugPlacebo 10 mg BID
Primary outcomes
-
Number of oocytes
Time frame: Approximately 5 weeks from first dose of study drug
Number of oocytes
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Barzilai Medical Center
Other
Registry information
Official study title
Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients: a Randomised, Double-blind, Placebo-controlled Trial
Important dates
- Study start
- 2021
- Primary completion
- 2027
- Study completion
- 2028
- First posted
- Jun 18, 2018
- Registry last updated
- Feb 10, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.