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Completed

NCT Number: NCT05190588

Efficacy of Mesotherapy in Patients With Knee Osteoarthritis

Purpose: The investigators aimed to determine whether this treatment is effective on pain and function by applying mesotherapy treatment to patients followed up with gonarthrosis.

Methods: This study is a prospective randomized controlled study. The research will be carried out between November 2021 and April 2022 in Pamukkale University Physical Medicine and Rehabilitation (PMR) After the approval of the Pamukkale University Faculty of Medicine Ethics Committee, 38 patients diagnosed with gonarthrosis will be divided into 2 groups using a table of random numbers. The first group will be the group that only applied quadriceps strength exercise and Mesotherapy will be applied to the second group along with quadriceps strength exercise.

The data will be analyzed with the SPSS package program. Continuous variables will be given as mean ± standard deviation and categorical variables as numbers and percentages. parametric test Test of Significance of Difference Between Two Means in comparison of independent group differences when assumptions are met; When parametric test assumptions are not met, the Mann-Whitney U test will be used to compare independent group differences. In addition, the relationships between continuous variables will be examined with Spearman or Pearson correlation analyzes and the differences between categorical variables will be examined with Chi-square analysis. Since there is no similar study conducted and there is no possibility to conduct a pilot study, assuming that a moderate effect size will be obtained as a result of the power analysis made in the direction of the hypothetical expectations, it was taken to obtain 80% power with 95% confidence, and it was calculated that at least 38 people should be included in the study.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pamukkale University

Denizli, None Selected, 20100, Turkey (Türkiye)

About this study

Detailed Description:

This study is a prospective randomized controlled study. The research will be carried out in Pamukkale University Physical Medicine and Rehabilitation (PMR) After the approval of the Pamukkale University Faculty of Medicine Ethics Committee,38 participants will be admitted to Pamukkale University PMR clinic will be included in this study. Patients will be informed about the content, purpose, and application of the study and their written consent will be obtained.

Treatment Protocol 38 patients diagnosed with gonarthrosis will be divided into 2 groups using random numbers table. The first group will be the group that only applied quadriceps strength exercise and Mesotherapy will be applied to the second group along with quadriceps strength exercise.

Group 1: Exercise Group (Quadriceps Strength)10 repetition in three-set, 5 times a week for three weeks Group 2: Mesotherapy (MT) once a week for three weeks. Patients will receive 2 ml of 2% lidocaine, 2 ml of pentoxifylline will be used. Sterile and disposable (0.26mm × 4mm and 0.3mm × 13 mm, Terumo) will be used for mesotherapy. and injection techniques (IDP=2-4 MM) AND (IDS=1-2 MM) will be used.

Statistics The data will be analyzed with the SPSS package program. Continuous variables will be given as mean ± standard deviation and categorical variables as numbers and percentages. parametric test

Test of Significance of Difference Between Two Means in comparison of independent group differences when assumptions are met; When parametric test assumptions are not met, the Mann-Whitney U test will be used to compare independent group differences. In addition, the relationships between continuous variables will be examined with Spearman or Pearson correlation analyzes and the differences between categorical variables will be examined with Chi-square analysis. Since there is no similar study conducted and there is no possibility to conduct a pilot study, assuming that a moderate effect size will be obtained as a result of the power analysis made in the direction of the hypothetical expectations, it was taken to obtain 80% power with 95% confidence, and it was calculated that at least 38 people should be included in the study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed as Knee Osteoarthritis according to ACR criteria

Exclusion criteria

  • Smaller than 40 years old
  • Those who give false and contradictory information,
  • Those who are poorly oriented with cooperation, -Patients using non-steroidal anti-inflammatory, patients with a history of knee surgery, --
  • Patients with meniscus lesions

Treatment and study plan

Mesotherapy

Other

Mesotherapy (MT) Sterile and disposable (0.26mm × 4mm and 0.3mm × 13 mm, Terumo) will be used. Patients will receive 2 ml of 2% lidocaine, 2 ml of pentoxifylline and will be used. Injection techniques (IDP=2-4 MM) AND (IDS=1-2 MM) will be used.

Primary outcomes

  1. VAS

    Time frame: 3 weeks

    Visual analogue scale (Total scale score can be ranged between 0 to 10. 0: no pain, 10:worst pain)

Secondary outcomes

  1. WOMAC scale

    Time frame: 3 weeks

    Western Ontario and McMaster Universities Osteoarthritis Index (Test Questions are scored on a scale of 0-4 which correpond to: none(0), mild(1), moderate (2), severe (3) extreme (4). The scores for each subscales are summed up with a possible score 0-20 for pain, 0-8 for stiffness, 0-68 for physical function.)

Sponsors and collaborators

Lead sponsor

Pamukkale University

Other

Registry information

Official study title

Efficacy of Mesotherapy on Pain and Function in Patients With Knee Osteoarthritis

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jan 13, 2022
Registry last updated
Nov 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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