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Completed

NCT Number: NCT04701008

Efficacy of Ketamine in Post Anesthesia Recovery Room

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

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Key information

Conditions

Pain, Postoperative Acute Pain Ketamine Adverse Reaction Neurologic Manifestations Pain Pain, Acute Pain, Intractable Pain, Refractory Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alberta Hospital

Edmonton, Alberta, t6g2b7, Canada

About this study

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.

After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.

The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.

Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:

  • age ≥ 18
  • significant pain despite narcotics used in post-anesthesia care unit
  • ketamine ordered by attending anesthesiologist

Exclusion criteria

  • Patient refusal to receive ketamine
  • Patients undergoing cardiac surgery
  • Patients who received no narcotics
  • Contra-indication to receiving ketamine (determined by attending anesthesiologist)

Treatment and study plan

ketamine

Drug

IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Primary outcomes

  1. Reduction in pain score after ketamine use in PACU

    Time frame: in the immediate post-operative period in recovery room

    The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain.

Secondary outcomes

  1. Incidence of side effects after ketamine use

    Time frame: in the immediate post-operative period in recovery room

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Official study title

Observational Study of the Efficacy of Ketamine for Rescue Analgesia in the Post Anesthesia Recovery Room

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jan 8, 2021
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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