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OpenTrials
Completed

NCT Number: NCT02285972

Efficacy of Intravenous Dexketoprofen and Tenoxicam on Propofol Associated Injection Pain

Propofol remains the most common drug for induction of general anaesthesia, although it causes considerable pain or discomfort on injection. Anesthesia providers have attempted a large number of remedies to prevent this pain on injection. Previously explored ideas include injecting propofol into larger veins, warming of the hand with hot packs, and intravenous pretreatment with numerous other medications. No studies to date have looked at the dexketoprofen and tenoxicam for the pretreatment of pain on injection caused by propofol. The investigators propose studying the use of dexketoprofen and tenoxicam for pretreatment of propofol related pain on injection.

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Key information

Conditions

Injection Pain

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital

Altinordu, Ordu, 52100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists (ASA) physical status 1 and 2
  • 18 - 65 years
  • general anesthesia scheduled for elective surgery

Exclusion criteria

  • age < 18 years, > 65 years
  • pregnancy
  • patients requiring a rapid sequence induction
  • refusal to participate and patients already participating in another study
  • allergy to study drugs
  • communication difficulty
  • psychiatric and neurolojic disorders
  • use of analgesics or sedative drugs within 24 hours before surgery.
  • emergency surgery
  • history of drug or alcohol abuse
  • ASA 3 and above

Treatment and study plan

Saline

Drug

before the anesthesia induction, 2mL saline iv injection

Other names: serum physiologic

Dexketoprofen

Drug

before the anesthesia induction, 50 mg (2mL) iv dexketoprofen

Other names: Arveles, Leodex

Tenoxicam

Drug

before the anesthesia induction, 20 mg (2mL) iv tenoxicam

Other names: Oksamen-L, Tilcotil

Primary outcomes

  1. Verbal Pain Score

    Time frame: Approximately one minute following administration of propofol.

  2. Facial Pain Score

    Time frame: Approximately one minute following administration of propofol.

Sponsors and collaborators

Lead sponsor

Ordu University

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Nov 7, 2014
Registry last updated
Apr 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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