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NCT Number: NCT06942702

Efficacy of Genicular Block on Total Knee Arthroplasty Surgery

The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:

1. Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block? 2. Does opioid consumption decrease in patients who underwent geniculate block?

Researchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.

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Key information

Conditions

Total Knee Anthroplasty Genicular Nerves Block Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Patients scheduled for knee arthroplasty will be randomly assigned into two groups. One group will receive a genicular nerve block prior to surgery , while the other group will not undergo any interventional procedure. The genicular nerve block will be administered in three quadrants around the knee, with each injection consisting of 5 mL of 0.25% Marcaine. All injections will be performed by investigator MA. Patient assessments will be conducted by investigator MO. Postoperative intravenous analgesia will be provided to both groups.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Scheduled for unilateral and primary total knee arthroplasty
  • Older than 18 years of age

Exclusion criteria

  • Younger than 18 years
  • Bilateral knee arthroplasty
  • Revision case of knee arthroplasty

Treatment and study plan

Genicular blocks (bupivakain)

Drug

Genicular block is a regional analgesic technique performed with USG

Patient Control Analgesia (PCA) Morphine group

Drug

this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Other names: PCA-M

Paracetamol (acetaminophen) + Diclofenac Sodium

Drug

All patients are given paracetamol (3x1000 mg) and diclofenac (if needed)

Primary outcomes

  1. Visual Analog Scale Measure

    Time frame: 0-48 hours

    VAS scores are assessed at 0th, 24th and 48th hours post operatively VAS score consists of 0-10 in numbers, the bigger the number the worse the pain

  2. opioid consumption

    Time frame: 0-48 hours

    Morphine consumption is assesed by PCA

Study contacts

Contact information is provided by the study sponsor or research team.

Mervenur Ozturk, Resident Doctor

CONTACT

[email protected]

+90 5525345189

Mustafa Azizoglu, Associated Professor

CONTACT

[email protected]

+90 5325667061

Sponsors and collaborators

Lead sponsor

Mersin University

Other

Registry information

Official study title

Assesment of Postoperative Analgesic Efficacy of Preoperatively Applied Genicular Block on Total Knee Arthroplasty: A Randomized Controlled Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 24, 2025
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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