Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial

The purpose of this study was to see if high dose esomeprazole (40mg bid) was effective in treating non-allergic rhinitis

Completed

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Key information

Conditions

Vasomotor Rhinitis Common Cold Deglutition Disorders Digestive System Diseases Esophageal Diseases Esophageal Motility Disorders Gastroesophageal Reflux Gastrointestinal Diseases Infections Laryngeal Diseases Laryngopharyngeal Reflux Nose Diseases Otorhinolaryngologic Diseases Picornaviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Rhinitis Rhinitis, Vasomotor Virus Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Trials Office, Aston Building, UT Southwestern

Dallas, Texas, 75390-9016, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age between 18-80, symptoms of perennial rhinitis, negative epicutaneous skin testing to a panel of common aeroallergens, and ability to speak English

Exclusion criteria

pregnancy or breast-feeding, evidence of positive skin tests to a common aeroallergen, treatment with a proton pump inhibitor within the month prior to enrollment, treatment with any other anti-reflux therapy within the last month on a daily basis or within the last two weeks on an as needed basis, and other gastrointestinal disorders leading to reflux symptoms

Treatment and study plan

Esomeprazole

Drug

40mg by mouth twice daily

Other names: Nexium

Placebo

Drug

Primary outcomes

Total Nasal Symptom Scores

Time frame: Last two weeks of each treatment arm

(1=none, 7=unbearably severe) difference in nasal symptom scores for the average of the last two weeks of each treatment arm

Sponsors and collaborators

Lead sponsor

University of Texas Southwestern Medical Center

Other

Collaborators

AstraZeneca

Registry information

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Sep 3, 2008
Registry last updated: Jun 11, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed