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Completed

NCT Number: NCT07240051

Efficacy of Different Types of Chemical Peels in the Treatment of Acne Vulgaris

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial.

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Key information

Conditions

Acne Acne Vulgaris Acneiform Eruptions Peeling Sebaceous Gland Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

Up to 65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo University

Cairo, 13114, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Facial active acne (mild and moderate cases)
  • post-acne hyperpigmentation
  • a minimum age of 18 years
  • skin phototype III or IV

Exclusion criteria

  • Pregnant or nursing women
  • active infection in the treatment area (e.g., verrucae and herpes simplex)
  • systemic disease (hypertension, diabetes, or bleeding tendency)
  • systemic retinoid or laser treatment within the last 6 months
  • history of keloidal tendency or Aspirin sensitivity.

Treatment and study plan

Glycolic acid peel alone

Procedure

Using a cotton tip applicator, a single coat of commercially prepared 50% GA peeling agent was evenly applied to the patient's face. Neutralization of the peel was done on reaching uniform erythema (endpoint) within 3-5 minutes. If frosting was observed in any area before the set time or endpoint, the area was neutralized with sodium bicarbonate

salicylic acid

Procedure

Using a cotton tip applicator, a single coat of commercially prepared 30% SA peeling agent was evenly applied to the patient's face, moving from the forehead and advancing to the cheeks, chin, glabella, nose, and perioral area. Once white crystallization appeared, patients were asked to wash their faces with water.

modified jessener

Procedure

Commercially prepared MJ peel was applied using a gauze piece and light hand pressure. A single coat of peel was uniformly applied over the entire face. The coat was allowed to dry completely until erythema or frosting occurred, at which point patients were asked to wash their faces with cold water.

Primary outcomes

  1. improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Nahla Maher Mahmoud Mahran

Other

Registry information

Official study title

Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial

Acronym: AV

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Nov 20, 2025
Registry last updated
Nov 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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