Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation

This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy. We compare between 2 combinations as regard hemodynamic stability, post operative side effects as occurrence of delirium, nausea, vomiting, headache, hallucination or agitation.

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Key information

Conditions

Propofol

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sohag University Hospital

Sohag, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

American Society of Anesthesiologists physical status I to II.
Age between 18 and 60 years.
Both sexes.

Exclusion criteria

Having severe heart, lung, liver disease, kidney failure, or bleeding disorder.
Patients having fever, hypothermia or infection, electrolyte disorders, such as hypokalemia and hypocalcaemia, acid-base disorder, allergy to drugs to be used.

Treatment and study plan

Dexmedetomidine-Propofol

Drug

efficacy of sedation with Dexmedetomidine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Ketamine-Propofol

Drug

efficacy of sedation with Ketamine-Propofol combination in the upper or lower gastrointestinal system endoscopy.

Primary outcomes

intraoperative and postoperative monitoring of sedation during upper or lower gastrointestinal system endoscopy.

Time frame: every 5 minutes intraoperative and every 15 minutes for 2 hours postoperative.

Sedation level

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation During Gastrointestinal Endoscopy

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jan 3, 2025
Registry last updated: May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed