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NCT Number: NCT05631405

Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)

The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.

Recruiting

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Key information

Conditions

Severe Dengue Arbovirus Infections Dengue Flaviviridae Infections Flavivirus Infections Hemorrhagic Fevers, Viral Infections Mosquito-Borne Diseases RNA Virus Infections Vector Borne Diseases Virus Diseases

Age range

7 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chulalongkorn University, Bangkok, Thailand

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test)
  • And still in febrile phase (Body temp>37.5 C)
  • Shock : Sys<90mmHg or Narrow PP (<20mmHg) orTachycardia (pulse>100/min) with Hematocrit decreased ≥20 %
  • Fluid accumulation and respiratory distress
  • Severe bleeding
  • Severe organ involvement

Exclusion criteria

  • Severe dengue> 24 hrs
  • Dengue without warning signs
  • Pregnancy
  • Patient who receieved any steroid within 1 week

Treatment and study plan

Dexamethasone

Drug

Patients treated with dexamethasone

Placebo

Drug

Patients treated with placebo

Primary outcomes

  1. Mortality

    Time frame: 28 days

    The use of steroids in dengue will reduce mortality in rate

Secondary outcomes

  1. Length of hospital stay

    Time frame: 28 days

    The use of steroids in dengue will reduce Length of hospital stay in day

Sponsors and collaborators

Lead sponsor

Chulalongkorn University

Other

Registry information

Official study title

Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Nov 30, 2022
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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