Efficacy of Clobetasol Vs Intralesional Triamcinolone in Lichen Planus Treatment

This is a randomized, single-blind (outcome assessor blinded), parallel-group clinical trial conducted at the Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan. A total of 116 eligible participants (58 per group) aged 18 and older with a confirmed diagnosis of hypertrophic lichen planus will be enrolled via consecutive sampling. Group A will receive topical Clobetasol propionate 0.05% cream twice daily for 12 weeks. Group B will receive intralesional Triamcinolone acetonide (10 mg/mL, 0.1-0.2 mL per site spaced 1 cm apart, max 0.5 mL/cm²) at weeks 0, 4, 8, and 12. Outcome parameters (LPSI, pruritus VAS, and lesion area in cm²) will be recorded at baseline, week 4, week 8, and week 12 to statistically evaluate and compare clinical response rates and the incidence of adverse drug reactions between the two treatment modalities.

Inclusion criteria

• Age >= 18 years, both genders[cite: 1]
• Confirmed clinically as hypertrophic lichen planus with Lichen Planus Severity Index (LPSI) score >= 2 at baseline and Pruritus Visual Analog Scale (VAS) score >= 4 at baseline[cite: 1]
• No use of topical or intralesional treatment of lichen planus within the last 4 weeks[cite: 1]
• Able to provide written informed consent in English or Urdu language[cite: 1]

Exclusion criteria

• Drug-induced lichenoid lesions[cite: 1]
• Pregnant or lactating women[cite: 1]
• Uncontrolled diabetes mellitus or any other active skin infections[cite: 1]
• Necessity of systemic corticosteroids or immunosuppressive drugs as the primary treatment[cite: 1]
• Previous history of hypersensitivity or sensitivity to the study medicines (clobetasol propionate or triamcinolone acetonide)[cite: 1]
• Refusal to provide informed consent[cite: 1]